DetoxFungiV1, Main, Exploration, bibRecord, 000396

Proteomic characterization of the arsenic response locus in S. cerevisiae.

Identifieur interne : 000396 ( Main/Exploration ); précédent : 000395; suivant : 000397

Proteomic characterization of the arsenic response locus in S. cerevisiae.

Auteurs : Kirk L. West [États-Unis] ; Stephanie D. Byrum [États-Unis] ; Samuel G. Mackintosh [États-Unis] ; Rick D. Edmondson [États-Unis] ; Sean D. Taverna [États-Unis] ; Alan J. Tackett [États-Unis]

Source :

Epigenetics [ 1559-2308 ] ; 2019.

RBID : pubmed:30739529

Descripteurs français

KwdFr :
- Analyse de profil d'expression de gènes (MeSH), Arsenate Reductases (génétique), Arsenic (pharmacologie), Facteurs de transcription à motif basique et à glissière à leucines (génétique), Protéines de Saccharomyces cerevisiae (génétique), Protéines de Saccharomyces cerevisiae (métabolisme), Protéines de répression (génétique), Protéines de transport membranaire (génétique), Protéomique (méthodes), Régions promotrices (génétique) (MeSH), Régulation de l'expression des gènes fongiques (effets des médicaments et des substances chimiques), Saccharomyces cerevisiae (croissance et développement), Saccharomyces cerevisiae (métabolisme), Systèmes CRISPR-Cas (MeSH).
MESH :
- croissance et développement : Saccharomyces cerevisiae.
- effets des médicaments et des substances chimiques : Régulation de l'expression des gènes fongiques.
- génétique : Arsenate Reductases, Facteurs de transcription à motif basique et à glissière à leucines, Protéines de Saccharomyces cerevisiae, Protéines de répression, Protéines de transport membranaire.
- métabolisme : Protéines de Saccharomyces cerevisiae, Saccharomyces cerevisiae.
- méthodes : Protéomique.
- pharmacologie : Arsenic.
- Analyse de profil d'expression de gènes, Régions promotrices (génétique), Systèmes CRISPR-Cas.

English descriptors

KwdEn :
- Arsenate Reductases (genetics), Arsenic (pharmacology), Basic-Leucine Zipper Transcription Factors (genetics), CRISPR-Cas Systems (MeSH), Gene Expression Profiling (MeSH), Gene Expression Regulation, Fungal (drug effects), Membrane Transport Proteins (genetics), Promoter Regions, Genetic (MeSH), Proteomics (methods), Repressor Proteins (genetics), Saccharomyces cerevisiae (growth & development), Saccharomyces cerevisiae (metabolism), Saccharomyces cerevisiae Proteins (genetics), Saccharomyces cerevisiae Proteins (metabolism).
MESH :
- chemical , genetics : Arsenate Reductases, Basic-Leucine Zipper Transcription Factors, Membrane Transport Proteins, Repressor Proteins, Saccharomyces cerevisiae Proteins.
- chemical , metabolism : Saccharomyces cerevisiae Proteins.
- chemical , pharmacology : Arsenic.
- drug effects : Gene Expression Regulation, Fungal.
- growth & development : Saccharomyces cerevisiae.
- metabolism : Saccharomyces cerevisiae.
- methods : Proteomics.
- CRISPR-Cas Systems, Gene Expression Profiling, Promoter Regions, Genetic.

Abstract

Arsenic exposure is a global health problem. Millions of people encounter arsenic through contaminated drinking water, consumption, and inhalation. The arsenic response locus in budding yeast is responsible for the detoxification of arsenic and its removal from the cell. This locus constitutes a conserved pathway ranging from prokaryotes to higher eukaryotes. The goal of this study was to identify how transcription from the arsenic response locus is regulated in an arsenic dependent manner. An affinity enrichment strategy called CRISPR-Chromatin Affinity Purification with Mass Spectrometry (CRISPR-ChAP-MS) was used, which provides for the proteomic characterization of a targeted locus. CRISPR-ChAP-MS was applied to the promoter regions of the activated arsenic response locus and uncovered 40 nuclear-annotated proteins showing enrichment. Functional assays identified the histone acetyltransferase SAGA and the chromatin remodelling complex SWI/SNF to be required for activation of the locus. Furthermore, SAGA and SWI/SNF were both found to specifically organize the chromatin structure at the arsenic response locus for activation of gene transcription. This study provides the first proteomic characterization of an arsenic response locus and key insight into the mechanisms of transcriptional activation that are necessary for detoxification of arsenic from the cell.

DOI: 10.1080/15592294.2019.1580110
PubMed: 30739529
PubMed Central: PMC6557609

Affiliations:

Links toward previous steps (curation, corpus...)

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Le document en format XML

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<term>Arsenic (pharmacology)</term>
<term>Basic-Leucine Zipper Transcription Factors (genetics)</term>
<term>CRISPR-Cas Systems (MeSH)</term>
<term>Gene Expression Profiling (MeSH)</term>
<term>Gene Expression Regulation, Fungal (drug effects)</term>
<term>Membrane Transport Proteins (genetics)</term>
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<term>Arsenic (pharmacologie)</term>
<term>Facteurs de transcription à motif basique et à glissière à leucines (génétique)</term>
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<term>Régulation de l'expression des gènes fongiques (effets des médicaments et des substances chimiques)</term>
<term>Saccharomyces cerevisiae (croissance et développement)</term>
<term>Saccharomyces cerevisiae (métabolisme)</term>
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<term>Basic-Leucine Zipper Transcription Factors</term>
<term>Membrane Transport Proteins</term>
<term>Repressor Proteins</term>
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<term>Protéines de Saccharomyces cerevisiae</term>
<term>Protéines de répression</term>
<term>Protéines de transport membranaire</term>
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<front><div type="abstract" xml:lang="en">Arsenic exposure is a global health problem. Millions of people encounter arsenic through contaminated drinking water, consumption, and inhalation. The arsenic response locus in budding yeast is responsible for the detoxification of arsenic and its removal from the cell. This locus constitutes a conserved pathway ranging from prokaryotes to higher eukaryotes. The goal of this study was to identify how transcription from the arsenic response locus is regulated in an arsenic dependent manner. An affinity enrichment strategy called CRISPR-Chromatin Affinity Purification with Mass Spectrometry (CRISPR-ChAP-MS) was used, which provides for the proteomic characterization of a targeted locus. CRISPR-ChAP-MS was applied to the promoter regions of the activated arsenic response locus and uncovered 40 nuclear-annotated proteins showing enrichment. Functional assays identified the histone acetyltransferase SAGA and the chromatin remodelling complex SWI/SNF to be required for activation of the locus. Furthermore, SAGA and SWI/SNF were both found to specifically organize the chromatin structure at the arsenic response locus for activation of gene transcription. This study provides the first proteomic characterization of an arsenic response locus and key insight into the mechanisms of transcriptional activation that are necessary for detoxification of arsenic from the cell.</div>
</front>
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<Abstract><AbstractText>Arsenic exposure is a global health problem. Millions of people encounter arsenic through contaminated drinking water, consumption, and inhalation. The arsenic response locus in budding yeast is responsible for the detoxification of arsenic and its removal from the cell. This locus constitutes a conserved pathway ranging from prokaryotes to higher eukaryotes. The goal of this study was to identify how transcription from the arsenic response locus is regulated in an arsenic dependent manner. An affinity enrichment strategy called CRISPR-Chromatin Affinity Purification with Mass Spectrometry (CRISPR-ChAP-MS) was used, which provides for the proteomic characterization of a targeted locus. CRISPR-ChAP-MS was applied to the promoter regions of the activated arsenic response locus and uncovered 40 nuclear-annotated proteins showing enrichment. Functional assays identified the histone acetyltransferase SAGA and the chromatin remodelling complex SWI/SNF to be required for activation of the locus. Furthermore, SAGA and SWI/SNF were both found to specifically organize the chromatin structure at the arsenic response locus for activation of gene transcription. This study provides the first proteomic characterization of an arsenic response locus and key insight into the mechanisms of transcriptional activation that are necessary for detoxification of arsenic from the cell.</AbstractText>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>West</LastName>
<ForeName>Kirk L</ForeName>
<Initials>KL</Initials>
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<AffiliationInfo><Affiliation>a Department of Biochemistry and Molecular Biology , University of Arkansas for Medical Sciences , Little Rock , AR , USA.</Affiliation>
</AffiliationInfo>
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<Author ValidYN="Y"><LastName>Byrum</LastName>
<ForeName>Stephanie D</ForeName>
<Initials>SD</Initials>
<Identifier Source="ORCID">0000-0002-1783-3610</Identifier>
<AffiliationInfo><Affiliation>a Department of Biochemistry and Molecular Biology , University of Arkansas for Medical Sciences , Little Rock , AR , USA.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>b Arkansas Children's Research Institute , Little Rock , AR , USA.</Affiliation>
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<Author ValidYN="Y"><LastName>Mackintosh</LastName>
<ForeName>Samuel G</ForeName>
<Initials>SG</Initials>
<AffiliationInfo><Affiliation>a Department of Biochemistry and Molecular Biology , University of Arkansas for Medical Sciences , Little Rock , AR , USA.</Affiliation>
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<Author ValidYN="Y"><LastName>Edmondson</LastName>
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<Initials>RD</Initials>
<AffiliationInfo><Affiliation>c College of Medicine , University of Arkansas for Medical Sciences , Little Rock , AR , USA.</Affiliation>
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<Author ValidYN="Y"><LastName>Taverna</LastName>
<ForeName>Sean D</ForeName>
<Initials>SD</Initials>
<AffiliationInfo><Affiliation>d Department of Pharmacology and Molecular Sciences , The Johns Hopkins University School of Medicine , Baltimore , MD , USA.</Affiliation>
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<AffiliationInfo><Affiliation>a Department of Biochemistry and Molecular Biology , University of Arkansas for Medical Sciences , Little Rock , AR , USA.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>b Arkansas Children's Research Institute , Little Rock , AR , USA.</Affiliation>
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<ISSNLinking>1559-2294</ISSNLinking>
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<ChemicalList><Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="C109281">ACR3 protein, S cerevisiae</NameOfSubstance>
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<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D050976">Basic-Leucine Zipper Transcription Factors</NameOfSubstance>
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<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D026901">Membrane Transport Proteins</NameOfSubstance>
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<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="C077832">SKO1 protein, S cerevisiae</NameOfSubstance>
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<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D029701">Saccharomyces cerevisiae Proteins</NameOfSubstance>
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<Chemical><RegistryNumber>EC 1.20.-</RegistryNumber>
<NameOfSubstance UI="C506971">ARR2 protein, S cerevisiae</NameOfSubstance>
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<Chemical><RegistryNumber>EC 1.20.-</RegistryNumber>
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Proteomic characterization of the arsenic response locus in S. cerevisiae.

Proteomic characterization of the arsenic response locus in S. cerevisiae.

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